Lorsqu'un vieux pote, le défunt Stéphane, se met a poster sur
internet des vidéos de l'au-dela, ULTIMEX et Steve réalisent que
l'enfer existe vraiment.Vu leur lourd passif, c'est sacrément mal
barré pour eux. Ils décident donc d'aller aux enferspour botter le
cul de Lucifer.`Une histoire en deux tomes, bourrés de bonne
testostérone, d'alcool et de substances douteuses.
On a tous un Blond autour de nous !
On a tous un pote qui sait tout sur tout, un pote super sportif, un pote super sociable... Eh bien, le Blond, c'est un peu tous ces mecs à la fois et bien plus encore. Le Blond, il a son propre langage : il commence toutes ses phrases par " Dis donc ! ", ponctue chaque moment-clé par " Pim, pam, poum " et les termine par " C'est pourtant simple ! ".
Vous savez ? Le Blond, celui qui fait un " clac clac " parfait en enfilant ses chaussures de ski, un " schpluf " qui n'asperge pas quand il plonge, qui ne transpire pas quand il danse all night long en boîte de nuit, qui a fait " option Ikea 3e langue " et donc pour qui monter un meuble Flürgoeburg est un jeu d'enfant... Voilà, LUI !
LUI ! Celui qui nous renvoie à notre propre condition d'être humain tout simplement normal, c'est-à-dire bancal, c'est-à-dire parfois paumé, qui peut avoir la poisse. Celui qui choisit systématiquement la mauvaise caisse au supermarché, celui dont la mayonnaise de son sandwich va forcément s'étaler sur son pantalon, celui qui dévalera au moins une fois les pistes de ski à l'envers, celui pour qui le guichet de l'administration fermera juste devant lui après une heure et demie d'attente, celui qui a peur en avion, celui pour qui faire un jogging relève du masochisme, bref, L'AUTRE : vous, moi.
Il était temps de lui donner un visage. C'est ce que font admirablement Gad Elmaleh, Bastien Pasquier et Jean-Baptiste Hostache, en adaptant certains sketches existants de Gad, mais aussi et surtout en créant des scénarios inédits pour cet album.
Le Blond a encore pas mal de choses à nous apprendre...
Dans ce tome 2, le Blond ne cesse de nous surprendre : il a un troisième Blond (easy, évidemment, ça ne change rien si ce n'est une dose de bonheur supplémentaire) ; il change de boulot (oui, il excelle dans son travail de chercheur - ou plutôt de " trouveur " puisqu'il est le seul chercheur à trouver -, mais à quoi bon stagner et ne pas pimenter sa vie ?) ; il concilie à merveille vie de famille, vie sociale et vie amicale, les sorties scolaires, les activités sportives (les siennes mais aussi celles des enfants, bien entendu), sans jamais négliger sa douce qu'il aime par-dessus tout... Le Blond, quoi !!!
Dans ce tome 2, le Blond et l'Autre se connaissent, se côtoient, se rendent des services, leurs enfants s'invitent à leurs goûters d'anniversaire... un peu comme dans notre vie à tous, en somme. Car oui, vous aussi, enfin nous aussi, nous avons une famille de Blonds autour de nous.
Et aussi agaçants, déconcertants, exaspérants, crispants soient-ils, on n'y peut rien, ils sont attachants, les Blonds. Et ça, c'est fort. Du Blond, du vrai.
Michel Louis, la petite quarantaine, plombier, se lie d'amitié avec Maître Delage, qu'il rencontre pour son divorce. Séduit par les études et par le nouveau milieu qu'il fréquente grâce à son mentor, il devient avocat et se transforme jusqu'à aller beaucoup plus loin que lui. Influencé par son élève, Maître Delage change lui aussi : il se décontracte, profite de la vie et même s'encanaille. Les deux personnages se fondent, tant l'influence des deux s'imbriquent.
A l'instar des visages, les noms nous identifient, ils portent l'histoire des ancêtres et se portent, voire se transportent de génération en génération : transmission du patronyme, du nom dit de famille. Les noms " collent à la peau " et à vouloir s'en séparer, ils reviennent comme des signifiants de l'origine. Dans la tradition juive, le nom apparaît comme vecteur de sens. Le premier acte d'Adam, écrit la Genèse, est de nommer tous les animaux et tous les oiseaux que Dieu avaient créés, puis de nommer sa femme Eve. A faire la route (de l'exil), nombreux sont les juifs qui ont changé un " nom à coucher dehors " car ce nom, parfois difficilement prononçable, les identifiait comme venant d'ailleurs, risquant de freiner leur intégration et leur promotion sociale. Avec l'espoir que franciser son nom pourrait éviter de nouvelles persécutions. Comment les noms nous identifient-ils ? De quels lieux sont-ils l'écho ? De quelle manière nous approprions-nous nos noms ? Et quel regard les autres portent-ils, au fond, sur notre patronyme ?
L'auteur de « OEil du ciel : coeur et de Main planétaire », avec ce nouveau recueil de poèmes, dans un esprit logique, s'interroge sur de graves questions : le « silence », la « géométrie » et l'idée de « centre ». Pour le poète qu'il est, le silence apparaît comme un « drap de lit étendu comme un empire » ; il symbolise l'arrêt du temps, il peut être visualisé par la « surface du lac ». Il est souvent « le silence absence » d'après l'amour. Il est à la fois « fin et attente ». Il est d'un « blanc contaminé ». Un oiseau blanc « efface les traces » d'un bruit dans le ciel, par exemple. Il nous permet de ressentir « l'unité universelle ». Puisque l'invisible représente les neuf dixièmes de l'univers connu, « l'île invisible » que nous quêtons peut donc se trouver n'importe où. Notons que le vent ne trouble pas le silence. La « géométrie » reste impassible aux outrages du temps. La ligne droite peut onduler, la spirale s'enrouler, « le temps s'écrase au dur de la géométrie », « digère l'élasticité ». Dans le chaos seul l'esprit « se meut en toute liberté ». Pour le poète, la géométrie est « la colonne vertébrale du monde ». La pierre brute cède à la graine. Remarquons l'accord cousin du cercle et du triangle. Dans le « buisson géométrique des murs », le temps accepte le sommeil humain, lequel va nous ouvrir « la liberté compensatrice, de l'irréel ». Pouvoirs de l'onirisme. Les deux mains en prière, le triangle du corps, l'extase. « Le beau total est mystique, l'extase le vide vécu,... vaincu ». « Tout commence par le relief et finit par la séparation ». Le triangle est émancipation. Le « centre » est une exception. Quelque chose pousse de l'extérieur vers la « pureté du point », la « justice absolue », voire « le secret ». Le silence, lui, n'a pas de centre. « Le centre un - Dieu Un... éternité du centre ». Le poète achève son recueil par l'éloge de la « centritude certitude ». Il est rare qu'un poète, avec des moyens de poète, images et convictions, puisse nous fasciner par des considérations abstraites. Pic Adrian y est parvenu. Ce n'est pas un mince compliment.
Best practices for conducting effective and safe clinical trials Clinical trials are arguably the most important steps in proving drug effectiveness and safety for public use. They require intensive planning and organization and involve a wide range of disciplines: data management, biostatistics, pharmacology, toxicology, modeling and simulation, regulatory monitoring, ethics, and particular issues for given disease areas. Clinical Trials Handbook provides a comprehensive and thorough reference on the basics and practices of clinical trials. With contributions from a range of international authors, the book takes the reader through each trial phase, technique, and issue. Chapters cover every key aspect of preparing and conducting clinical trials, including: Interdisciplinary topics that have to be coordinated for a successful clinical trialData management (and adverse event reporting systems) Biostatistics, pharmacology, and toxicology Modeling and simulation Regulatory monitoring and ethics Particular issues for given disease areas-cardiology, oncology, cognitive, dementia, dermatology, neuroscience, and more With unique information on such current issues as adverse event reporting (AER) systems, adaptive trial designs, and crossover trial designs, Clinical Trials Handbook will be a ready reference for pharmaceutical scientists, statisticians, researchers, and the many other professionals involved in drug development.
This resource guides prescribers, pharmacists, and regulators with an update on the recent expansion of basic and clinical knowledge that forms a framework for understanding cutaneous reactions. This understanding will lead, in turn, to better outcomes and decisions in treatment and management, both in the clinic and in the life cycle of drug development.
The skin is a common target for adverse drug events and even mild rashes can be part of life-threatening syndromes. Patients and practitioners often face important decisions about therapy after a drug eruption, including treatment, cross-reactivity with future pharmaceuticals, genetic considerations and dealing with long-term sequelae after a reaction. An international team of experts and leaders in the field share their story and insights into the scientific details and relevant clinical context.
This book is built around the use of readymade soft processor cores for FPGA design. In particular, the book focuses on Altera FPGA boards. The book explores many different embedded systems needs and prepares its readers for hands-on design and development of such systems. Many worked-out examples and case studies have been included to enable a clear understanding of design concepts. Primarily designed as a textbook for core or lab courses on FPGA based embedded systems, this book will appeal to students and instructors alike. The book takes an autodidactic approach, which also makes it suitable for hobbyists and practitioners looking to acquaint themselves with Altera FPGA boards.
Escherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection.
This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.
With its coverage of Food and Drug Administration regulations, international regulations, good manufacturing practices, and process analytical technology, this handbook offers complete coverage of the regulations and quality control issues that govern pharmaceutical manufacturing. In addition, the book discusses quality assurance and validation, drug stability, and contamination control, all key aspects of pharmaceutical manufacturing that are heavily influenced by regulatory guidelines. The team of expert authors offer you advice based on their own firsthand experience in all phases of pharmaceutical manufacturing.
The last 10 years have seen a seismic shift in therapeutic product development and testing. In both the pharmaceutical (both small and large molecule) and medical device sectors, the vast majority of testing and evaluation of products is not performed within innovator companies, but rather has been outsourced to a growing universe of commercial organizations. The authors both have more than 30 years experience in this field, and both have worked within innovator companies, for CROs, and as consultants in the field. Contract Research and Development Organizations: Their Role in Global Product Development has been crafted by these authors to provide a how to guide for all aspects of working with CROs in selecting, working with and ensuring the best possible desirable outcome of having the R&D function, or substantial parts of it, outsourced. It uses as the exemplary case nonclinical safety assessment, biocompatibility and efficacy testing which are to be performed to select the best possible candidate compound, device or formulation and then moving the resulting regulated therapeutic medical product into and through the development process and to marketing approval. But also covered are the contract synthesis of drug substances and corresponding manufacture of biologics and manufacture of products, formulation development, clinical evaluation, regulatory and document preparation support, and use of consultants.Included in the volume are an exhaustive listing of those CROs in the (drug and device) safety evaluation sector and their contact information and capabilities, and extensive similar listing for the other types of contract service providers. Also included are guidances on how to monitor ongoing work at contract facilities and audit check lists for GLP, GMP and GCP facilities. These listings are international in scope, and a specific chapter addresses working with some of the newer international CROs.
A clear, straightforward resource to guide you through preclinical drug development
Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques.
Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear.
Among the key topics covered are:
Modeling and informatics in drug design
Absorption of drugs after oral administration
Transporter interactions in the ADME pathway of drugs
Mechanisms and consequences of drug-drug interactions
Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage.
This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.
The inspiration for this text was the 1988 volume by Alder and Zbinden, written before the ICH harmonization process for drug safety evaluation (or its ISO analog for device biocompatibility evaluation) had been initiated or come to force. Since then, much has changed in both the world and practice of medicine and the regulation of drugs. The intent of this volume is to provide similar guidance as to what nonclinical safety assessment tests need to be performed to move a drug into man, through development and to market approved (this intent was subsequently extended to cover the closely related medical device biotechnology, and combination product fields) in a concise, abbreviated manner for all the major world market countries.
Designing satellite structures poses an ongoing challenge as the interaction between analysis, experimental testing, and manufacturing phases is underdeveloped. Finite Element Analysis for Satellite Structures: Applications to Their Design, Manufacture & Testing explains the theoretical and practical knowledge needed to perform design of satellite structures. By layering detailed practical discussions with fully developed examples, Finite Element Analysis for Satellite Structures: Applications to Their Design, Manufacture & Testing provides the missing link between theory and implementation. Computational examples cover all the major aspects of advanced analysis; including modal analysis, harmonic analysis, mechanical and thermal fatigue analysis using finite element method. Test cases are included to support explanations an a range of different manufacturing simulation techniques are described from riveting to shot peening to material cutting. Mechanical design of a satellites structures are covered in three steps: analysis step under design loads, experimental testing to verify design, and manufacturing. Stress engineers, lecturers, researchers and students will find Finite Element Analysis for Satellite Structures: Applications to Their Design, Manufacture & Testing a key guide on with practical instruction on applying manufacturing simulations to improve their design and reduce project cost, how to prepare static and dynamic test specifications, and how to use finite element method to investigate in more details any component that may fail during testing.
Culture is seen as a source for the development of society. Task of cultural policy is therefore to create and support structures that promote mobilization of creativity of the people and thus ensure welfare, innovation and pluralism. Such relationships have been discussed at the level of UNESCO for the past forty years. Within Germany and Europe as well as on the African continent experiences and initiatives are increasing in order to put discourse on cultural policies into practice. There is a need to provide a forum for the exchange of concepts and to identify the state of the art of theory and practice within the concepts of good governance and cultural policy. It is essential to clarify the role and the needed context of the arts, of art education and of individual artists in the development of society.
This book describes the application of non-destructive geophysical methods in subsurface archaeological features. Such non-destructive methods are magnetometry, electrical resistance, electromagnetic conductivity, magnetic susceptibility and ground penetrating radar. This book also includes the last improvements in instrumentation, data processing, and interpretations of the collected data sets leading to the rapid progress in geophysical applications in the field of archaeological investigations. The book also provides complete case-studies and archaeological interpretation obtained our results carried out in different localities around the world.
This volume provides a complete update of all the materials in prior volumes on the subject (including current directories to testing labs and other support establishments worldwide), while adding substantial new material on the following topics:
· The history of CROs, including snapshots of CROs and a genealogy chart making clear where they came from and where they went.
· Study directors and principal investigators.
· The nuts and bolts of study performance.
· Electronic reporting requirements - SEND and eCTD (required for NDA, BLA, ANDA, and IND submissions).
· Consultants and their roles.
· An expanded examination of common problems and their solutions.
This book boasts complete directories to the global universe of operating labs - where they are, how to contact them, and what they do (including special capabilities). Additionally, checklists for qualifying labs and manufacturing facilities - and for auditing studies and projects at such facilities - are included. It is directed at those in industry (specifically directed at those working for companies using CRO services) but will also be of interest to scientists or administrators working in research organizations themselves.
In this case, the contents of this new work are essential to the target reader because the work, regulations, and actors (CROs) have evolved and changed at a rapid pace in the 10 years since the earlier volume that the author published. Likewise, the companies using these services have come to all be almost completely dependent on outsourcing. The earlier texts remain the only source of their kind (paper or electronic) on the field and the only noncommercial guide to the global industry and this volume provides a complete update.
Over the course of evolution most plants have acquired the ability to defend themselves against most groups of pathogens, including the viruses. Many antiviral resistance phenomena have been known and studied for decades but, until recently, understanding of their underlying mechanisms has lagged behind. These phenomena include resistance to infection, resistance to virus translocation through the plant, recovery from infection and genetically defined resistance, together with the associated phenomena of the local lesion response, and induced, or acquired, resistance. The identification and cloning of plant resistance genes, characterization of downstream signaling components, and especially the explosion of data regarding gene-silencing mechanisms, has led to rapid progress in the investigation of natural resistance phenomena. Meanwhile, in plant virology there has been remarkable progress in the arenas of replication, movement proteins and plasmodesmatal gating, and in the discovery of gene silencing suppressors. Therefore, it seemed timely and appropriate to link older but still important data on the well known, `classical' resistance phenomena with the new information that has emerged during the last decade or so. We hope that this book will inspire further research in this area, as resistance presents the most economical and environmentally sound approach to control plant virus diseases. Future technologies that emerge from this research might include an improved ability to introduce resistance genes into virus-susceptible, agronomically important cultivars, to improve current pathogen-derived resistance strategies using our new knowledge of small interfering and microRNAs, or to develop targeted chemical treatments.
Start building Python-based Android applications using Kivy with Android Studio. Through in-depth examples, this book teaches you everything you need to create your first Android application in Python and publish on Google Play.Building Android Apps in Python Using Kivy with Android Studio takes you through the basics of Kivy by discussing its application structure, widgets, and event handling. The KV language is then introduced for separating the logic and GUI by adding widgets within a KV file. You will then learn how to utilize Android camera using Kivy, build the HTTP server using Flask, and create and manage multiple screens to help you design your own applications. Through detailed step-by-step instructions, you will create your first multi-level cross-platform game that includes animation and sound effects. Following this, the process of converting the Kivy application into an Android application using Buildozer and Python-4-Android is covered in detail. You will then learn how to edit the generated Android Studio project into Android Studio by adding extensions to the original application. The widgets added in Kivy could be handled within Android Studio. Moreover, Android views could be added to enrich the Kivy application. The resulting Android application created with Kivy can be hosted on Google Play to download and install as a regular Android application.At the end, this book will give you the basic knowledge of Kivy needed to build cross-platform Android applications, produce an Android Studio project, and understand how it all works in detail. What You Will LearnBuild cross-platform applications from scratch using Kivy in detailCreate a cross-platform interactive multi-level game from the ground upExamine the pipeline of building an Android app from the Python Kivy appUnderstand the structure of the Android Studio project produced by KivyRecognize how to extend the application within Android Studio by adding more Android views to the application main activity.
Who This Book Is ForPython developers with no previous experience in Kivy who are looking to create their first Android application completely in Python.
Bénita et Benjamin, amoureux, viennent de terminer leurs études et sont dans la vie active. N'est-ce pas que «l'homme quittera son père et sa mère et s'attachera à sa femme, et les deux feront une seule chair » ? Ils y ont cru, mais c'était sans compter avec une belle-mère envahissante et résolument décidée à pourrir la vie à sa bru. Ce furent des hauts et des bas, désillusions, motivations ; si Bénita pouvait ne plus aimer son mari...
Deploy deep learning applications into production across multiple platforms. You will work on computer vision applications that use the convolutional neural network (CNN) deep learning model and Python. This book starts by explaining the traditional machine-learning pipeline, where you will analyze an image dataset. Along the way you will cover artificial neural networks (ANNs), building one from scratch in Python, before optimizing it using genetic algorithms.
For automating the process, the book highlights the limitations of traditional hand-crafted features for computer vision and why the CNN deep-learning model is the state-of-art solution. CNNs are discussed from scratch to demonstrate how they are different and more efficient than the fully connected ANN (FCNN). You will implement a CNN in Python to give you a full understanding of the model.
After consolidating the basics, you will use TensorFlow to build a practical image-recognition model that you will deploy to a web server using Flask, making it accessible over the Internet. Using Kivy and NumPy, you will create cross-platform data science applications with low overheads.
This book will help you apply deep learning and computer vision concepts from scratch, step-by-step from conception to production.
What You Will Learn Understand how ANNs and CNNs work Create computer vision applications and CNNs from scratch using PythonFollow a deep learning project from conception to production using TensorFlowUse NumPy with Kivy to build cross-platform data science applications
Who This Book Is ForData scientists, machine learning and deep learning engineers, software developers.
All individuals who operate in the business sphere, whether as consumers, employers, employees, entrepreneurs, or financial traders to name a few constituents, share a common biological heritage and are defined by a universal human nature. As such, it is surprising that so few business scholars have incorporated biological and evolutionary-informed theories within their conceptual toolboxes. This edited book addresses this lacuna by culling chapters at the intersection of the evolutionary behavioral sciences and specific business contexts including in marketing, consumer behavior, advertising, innovation and creativity, intertemporal choice, negotiations, competition and cooperation in organizational settings, sex differences in workplace patterns, executive leadership, business ethics, store design, behavioral decision making, and electronic communication. To reword the famous aphorism of T. G. Dobzhansky, nothing in business makes sense except in the light of evolution.
While the safety assessment ("biocompatibility") of medical devices has been focused on issues of local tissue tolerance (irritation, sensitization, cytotoxicity) and selected quantal effects (genotoxicity and acute lethality) since first being regulated in the late 1950s, this has changed as devices assumed a much more important role in healthcare and became more complex in both composition and in their design and operation.Add to this that devices now frequently serve as delivery systems for drugs, and that drugs may be combined with devices to improve device performance, and the problems of ensuring patient safety with devices has become significantly more complex.A part of this, requirements for ensuring safety (once based on use of previously acceptable materials - largely polymers and metals) have come to requiring determining which chemical entities are potentially released from a device into patients (and how much is released). Then an appropriate and relevant (yet also conservative) risk assessment must be performed for each identified chemical structure. The challenges inherent in meeting the current requirements are multifold, and this text seeks to identify, understand, and solve all of them.o Identify and verify the most appropriate available data.o As in most cases such data is for a different route of exposure, transform it for use in assessing exposure by the route of interest.o As the duration (and rate) of exposure to moieties released from a device are most frequently different (longer) than what available data speaks to, transformation across tissue is required.o As innate and adaptive immune responses are a central part of device/patient interaction, assessing potential risks on this basis are required.o Incorporating assessments for special populations such as neonates.o Use of (Q)SAR (Quantitative Structure Activity Relationships) modeling in assessments.o Performance and presentation of integrative assessments covering all potential biologic risks.Appendices will contain summarized available biocompatibility data for commonly used device materials (polymers and metals) and safety assessments on the frequently seen moieties in extractions from devices.